The natural history of severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children: a systematic review. Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19) COVID-19 in the United States: Insights from Healthcare Systems Guidance for Certifying Deaths Due to Coronavirus Disease 2019 (COVID-19) MIS-C was first reported in April 2020 as a hyperinflammatory syndrome with variable features of Kawasaki disease.1 Most cases occur several weeks following confirmed or suspected severe acute respiratory syndrome coronavirus … Multisystem inflammatory syndrome in children (MIS-C) has become a recognized syndrome, whereas a parallel syndrome in adults has not been well defined. Other symptoms may include sore throat, rhinorrhoea, or congestion, myalgias, headache, fatigue, and gastrointestinal symptoms including nausea, vomiting, or diarrhoea. Because multisystem inflammatory syndrome in children (MIS-C; alternately known as paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 [PIMS-TS]) has only been identified since April, 2020, information on factors that are potentially linked to severe clinical outcomes has been scarce. It can rapidly lead to medical emergencies such as insufficient blood flow around the body (a condition known as shock). ### What you need to know The most common symptoms in children with acute SARS-CoV-2 infection (covid-19 disease) are fever and cough. 2020;9(6):746-751. doi: 10.1093/jpids/piaa112 PubMed Google Scholar Crossref Multisystem inflammatory syndrome in children (MIS-C), or paediatric inflammatory multisystem syndrome (PIMS / PIMS-TS), is a rare systemic illness involving persistent fever and extreme inflammation following exposure to SARS-CoV-2, the virus responsible for COVID-19.  J Pediatric Infect Dis Soc . The range of symptom prevalence is reported from three large meta-analyses, …
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